Happy Holidays

It’s Hard to Believe that it’s that time of year. Happy Holidays to everyone and here is a wonderful Holiday video for the occasion

Alzheimer’s Disease Treatments

Article #1

“Clip & save: drug chart. Drugs to treat Alzheimer’s disease.” Journal of Psychosocial Nursing & Mental Health Services 48.4 (2010): [9-10]. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This is a good article to start basic research on this topic. It lists several different drugs used for treatment, when they should be used and issues that the drugs cause.

Article #2

Cranwell-Bruce, LA. “Drugs for Alzheimer’s disease.” MEDSURG Nursing 19.1 (2010): 51-53. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.
This is a recent article also for basic research listing information about a two different types of treatments and the drugs related to those types of treatment.

Webpage #3

“Standard Treatments” Alzheimer’s Association. 2010 5 Dec 2010
<http://www.alz.org/alzheimers_disease_standard_prescriptions.asp>

This is an actual webpage however; the non-profit Alzheimer’s association dedicated to research and information about Alzheimer’s creates it. This site is useful for fining easily obtainable info about the disease open to the public in an easy to understand manner.

Webpage #4

“A Treatment Overview of Alzheimer’s Disease” WebMD. 2010 5 Dec 2010
<http://www.webmd.com/alzheimers/guide/treatment-overview>

This is another webpage created on a .com for profit domain as can be seen by the many ads on the page, however it is a source with again some basic
information which can be used look at about the disease.

Webpage #5

Hill, Carrie, PhD. “Alzheimer’s Treatment” About.com 2008 5 Dec 2010
<http://alzheimers.about.com/od/treatmentofalzheimers/a/treatments.htm>

Again this is a free an open source however it deals specifically with treatments and drugs used currently to treat Alzheimer’s disease.

Article #6

Hirsch, C. “Continued use of antipsychotic drugs increased long-term mortality in patients with Alzheimer disease.” ACP Journal Club 150.6 (2009): CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This Article is a little more in depth into the actual health of an Alzheimer’s patient’s well being based on the other drugs that the patient is on for behavior control.

Article #7

Panza, F, et al. “Beyond the neurotransmitter-focused approach in treating Alzheimer’s Disease: drugs targeting ß-amyloid and tau protein.” Aging Clinical & Experimental Research 21.6 (2009): 386-406. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This article discuses the affects of Alzheimer’s to the brain and the drugs, which target the ß-amyloid and tau protein, which have studied to be an effect of Alzheimer’s Disease. This is a very specific article on the disease.

Article #8

Grossberg, GT, C Sadowsky, and JT Olin. “Rivastigmine transdermal system for the treatment of mild to moderate Alzheimer’s disease.” International Journal of Clinical Practice 64.5 (2010): 651-660. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This resource lists another new type of treatment in trials being used for treating of Alzheimer’s, transdermal or through the skin vs. the standard oral treatment through pills. Similar to a patch for quitting smoking.

Article #9

McGuinness, B, et al. “Effective use of drugs in Alzheimer’s disease.” Practice Nursing 20.6 (2009): S11-4. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This article discusses different ideas and treatments for when a current treatment appears to be losing its productiveness when the patients decline more rapidly than expected.

Article #10

Ellul, J, et al. “The effects of commonly prescribed drugs in patients with Alzheimer’s disease on the rate of deterioration.” Journal of Neurology, Neurosurgery & Psychiatry 78.3 (2007): 233-239. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.
This is another article, which continues to look at the drugs and the deterioration rate. It is useful to look at to get an understanding of current treatments and their effects, on different patients and the interactions with other drugs.

Article #11

Hutchings, D, et al. “Cholinesterase inhibitors and Alzheimer’s disease: Patient, carer and professional factors influencing the use of drugs for Alzheimer’s disease in the United Kingdom.” Dementia (14713012) 9.3 (2010): 427-443. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This article discusses an actual study of people between 2001 to 2006 about the access to Alzheimer’s disease drugs, and the effect of money on access. This is a different type of article but it would be good to note and look at the topic of availability, as money is one of the major reasons research progresses so slowly.

Article #12

Disease-modifying drugs for Alzheimer’s: hope or hype?.” Harvard Mental Health Letter 24.4 (2007): 1-3. CINAHL with Full Text. EBSCO. Web. 5 Dec. 2010.

This article discusses the phases for upcoming drugs still in trial phases, and how none of these drugs will actually cure Alzheimer’s Disease, and that we should have cautions optimism. This article is from 2007 so it’s also good to compare what changes have been made if any in the past three years to our understanding and treatment of Alzheimer’s.

Article #13

Lon S. Schneider, Richard E. Kennedy, Gary R. Cutter “Requiring an amyloid-β1-42 biomarker for prodromal Alzheimer’s disease or mild cognitive impairment does not lead to more efficient clinical trials” Alzheimer’s and Dementia, Volume 6, Issue 5, September 2010, Pages 367-377. 5 Dec 2010.

This article is important, as it is an original research article discussing the results of clinical trials for the amyloid-β. Information on clinical trials are important as they could be new, up and coming fresh research which could eventually lead to a cure.

Article #14

Wei-Qin Zhao, Matthew Townsend. “Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer’s disease” Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease, Volume 1792, Issue 5, May 2009, Pages 482-496. 5 Dec 2010

This article discusses the similarities between type 2 diabetes, and Alzheimer’s disease, and how the glucose/insulin dependencies are related.

Article #15

Marta Giacomello, Laura Barbiero, Giancarlo Zatti, et al. “Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer’s disease presenilin-2 T122R mutation and anticipates the onset of dementia” Neurobiology of Disease, Volume 18, Issue 3, April 2005, Pages 638-648. 5 Dec 2010

This article relates to Article #14 discussing Ca2+, and it’s association with the causes of Mutations in PS1 and PS2 Genes, which cause familial Alzheimer’s disease. This is not directly a treatment but it is a good idea to research the causes of Alzheimer’s disease to be able to study the treatments.

Article #16

“How Statins May Protect against Alzheimer Disease”. PLoS Med 2(1): e22. 2005. 5 Dec 2010
<http://dx.plos.org/10.1371/journal.pmed.0020022>

This article goes back to treatment of Alzheimer’s and discusses how cholesterol reducers can help to lower the risk of Alzheimer’s disease. Again this article is good for comparison as it’s from 2005, and the study was done on animals so was in very early stages then and likely has progress since that point.

Wiki #17

Eriksen, Jason PhD. “Alzheimer’s Disease” MedPedia. 2007- 2010 5 Dec 2010
<http://wiki.medpedia.com/Alzheimer’s_Disease>

This is a wiki page discussing Alzheimer’s as a whole with treatments, and everything to start what you would need to know. This is a medial wiki so it’s easier to update and stay current when new ideas arrive, and is also edited by a PhD for accuracy.

Government Webpage #18

“Symptoms, Diagnosis and Treatment” NIH Medline Plus. Fall 2010 5 Dec 2010
<http://www.nlm.nih.gov/medlineplus/magazine/issues/fall10/articles/fall10pg19.html>

This is a Government run website which gives this page credibility, no actual author is listed but the source can be trusted as it’s a government page. It lists the ways to tell a person has Alzheimer’s and the related treatments.

Webpage #19

“Alzheimer’s treatments: What’s on the horizon?” Mayoclinic. 19 Aug 2010. 5 Dec 2010
<http://www.mayoclinic.com/health/alzheimers-treatments/AZ00048/METHOD=print>

This is not a government run webpage however it was linked off of search on Medline Plus which is a government run article database so it gives credibility to this page. This page discusses again the treatments but discusses how slow new treatments are to come, and all factors related to why. This page is more current than article #12 and would be good to use for comparison.

Article #20

Gatz M “Educating the Brain to Avoid Dementia: Can Mental Exercise Prevent Alzheimer Disease?” PLoS Med. 2(1): e7. 2005. 5 Dec 2010. <http://dx.plos.org/10.1371/journal.pmed.0020007>

This article, however old is good article as it discusses another type of treatment, which is prevention by keeping the mind actively working, and how that works. This would be a good topic to at least discuss as part of a paper on Alzheimer’s treatments

Video: The iPad Keynote in less than 180 Seconds

This video is a recap of Apple’s iPad announcement from Wednesday January 27th 2010. This video is meant to be a humorous representation of the keynote highlighting certain repeated words during the keynote. Enjoy!

Thank bodypainter99 on Youtube for the video.

Video: The Muppets: Bohemian Rhapsody

This video combines the muppets from The Muppet Show singing Queen’s Bohemian Rhapsody.

Video: Rowan Atkinson and Hugh Laurie Shakespeare Sketch

This is a video by comedian Rowan Atkinson again just like the past couple videos. In this video Rowan Atkinson and Hugh Laurie of House fame discuss rewrites for Hamlet

Video: Rowan Atkinson – Fatal Beatings

This is another video by the comedian Rowan Atkinson in which he is in charge of a school and discusses a students behavior with his father. Thanks to the Youtube up loader. Be warned there is one expletive at the end of the video.

Video: Rowan Atkinson Invisible Drum Kit

Keeping with the previous video this one is also of Rowan Atkinson playing the invisible Drum Kit

Photo: Fall Color

I decided to start posting picture every now and then from my large collection of photos. These photos will be taken by the Sony H50 camera mentioned in an earlier post. It also links to the full resolution 9-MP photo so that it can be used by anyone interested in this type of camera for comparison.
Fall Colors in Niagara Falls
This is a photo of fall colors on trees over looking the Whirlpool in Niagara Falls from Thompson’s Point.

Rowan Atkinson Guide To A Perfect First Date

The video for today is a comedy skit preformed by Rowan Atkinson who is famous for the Role of Mr. Bean during the British TV series and several movies.

No Video last Week.

Sorry about not having a video last week. I haven’t had internet for the past few days so I haven’t been to post. I hopefully will be able to post something for tomorrow but I don’t know yet.